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Anesthetic (or anaesthetic, see spelling differences) is a drug that causes anesthesia-reversible loss of sensation. These drugs are generally administered to facilitate surgery. A wide variety of drugs are used in modern
anesthetic practice. Many are rarely used outside of
anesthesia, although others are used commonly by all disciplines.
Anesthetics are categorized in to two classes: general
anesthetics, which cause a reversible loss of consciousness (general anesthesia), and local
anesthetics, which cause a reversible loss of sensation for a limited region of the body while maintaining consciousness.
Main article: Local anesthetic
lidocaine (also known as Lignocaine)
anesthetics are agents that prevent transmission of nerve impulses without causing unconsciousness. They act by binding to fast sodium channels from within (in an open state). Local
anesthetics can be either ester or amide based.
anesthetics (e.g., procaine, amethocaine, cocaine) are generally unstable in solution and fast-acting, and allergic reactions are common.
anesthetics (e.g., lidocaine, prilocaine, bupivicaine, levobupivacaine, ropivacaine, mepivacaine and dibucaine) are generally heat-stable, with a long shelf life (around 2 years). They have a slower onset and longer half-life than ester
anaesthetics, and are usually racemic mixtures, with the exception of levobupivacaine (which is S(-) -bupivacaine) and ropivacaine (S(-)-ropivacaine). These agents are generally used within regional and epidural or spinal techniques, due to their longer duration of action, which provides adequate analgesia for surgery, labor, and symptomatic relief.
Only preservative-free local
anesthetic agents may be injected intrathecally.
anesthetic drugs are
toxic to the heart (where they cause arrhythmia) and brain (where they may cause unconsciousness and seizures). Arrhythmias may be resistant to defibrillation and other standard treatments, and may lead to loss of heart function and death.
The first evidence of local anesthetic
toxicity involves the nervous system, including agitation, confusion, dizziness, blurred vision, tinnitus, a metallic taste in the mouth, and nausea that can quickly progress to seizures and cardiovascular collapse.
Toxicity can occur with any local
anesthetic as an individual reaction by that patient. Possible
toxicity can be tested with pre-operative procedures to avoid
toxic reactions during surgery.
Direct infiltration of local
anesthetic into skeletal muscle will cause temporary paralysis of the muscle. Peripheral nerve blocks are when a nerve block is a shot of
anesthetic near a specific nerve or group of nerves. It blocks pain in the part of the body supplied by the nerve. Nerve blocks are most often used for procedures on the hands, arms, feet, legs, or face. Epidural and spinal
anesthesia is a shot of
anesthetic near the spinal cord and the nerves that connect to it. It blocks pain from an entire region of the body, such as the belly, hips, or legs.
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